SOX2 REPRESSES HEPATITIS B VIRUS REPLICATION BY BINDING TO THE VIRAL ENHII/CP AND INHIBITING THE PROMOTER ACTIVATION

SOX2 Represses Hepatitis B Virus Replication by Binding to the Viral EnhII/Cp and Inhibiting the Promoter Activation

Hepatitis B virus (HBV) replication is controlled by four promoters (preS1, preS2, Cp, and Xp) and two enhancers (EnhI and EnhII).EnhII stimulates Cp Bumper Grille Guard activity to regulate the transcriptions of precore, core, polymerase, and pregenomic RNAs, and therefore, EnhII/Cp is essential for the regulation of HBV replication.This study rev

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Toward co-design of an AI solution for detection of diarrheal pathogens in drinking water within resource-constrained contexts.

Despite successes on the Sustainable Development Goals for access to improved water sources and sanitation, many low and middle-income countries (LMICs) continue to struggle with high rates of diarrheal disease.In Guatemala, 98% of water sources Top are estimated to have E.coli contamination.This project moves toward a novel low-cost approach to br

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